The scope of this extraordinary selection of essays, distilled from nearly a thousand works that the author has written, is literally the entire universe and universe of knowledge. It charts the author's quest for the meaning of life faced with a dominant knowledge system she regards as incoherent, meaningless, and often acting against people and planet. She shows how contemporary scientific findings across all disciplines already provide an authentic knowledge system that's coherent with life and the universe. The aim is to transform science thoroughly from inspiration to research to applications that work for people and planet. This book is simply unique in its scope and content. There is no equivalent. The author surveys and explains contemporary science in depth ranging over philosophy, anthropology, quantum physics and chemistry, neurobiology, psychology, genetics and epigenetics, cosmology, art, humanities, and mathematics. It presents a truly holistic view of nature, with profound implications for life in the social, political, and personal realm.