The religious fact is again a subject of much interest and social debate in the Bolivarian Republic of Venezuela in the 21st century. Social and political changes at the national and international level have a lot to do with it, but also with the development of Venezuelan society itself and the transformations within it brought about by the global change in beliefs. From the perspective of the Afro-Venezuelan spiritual ethno-history, religious Afropluralism and religion, Venezuela is very different from what it was a decade ago and is faced with remembering this diversity. The congenital birth of the spiritual gifts and laws of Africans brought as slaves significantly influenced Afro-Venezuelan healers and now the Afro-Venezuelan political and religious culture of the 21st century. Thus I express, that the Afro-descendants from Africa with their ancestral knowledge about the spirituality today known as Afro-spirituality, made evident in our lands where many Afro-Venezuelan communities were formed, level as well as the Afro-Latin American, Afro-Spanish and Afro-Venezuelan politics emerged in this new millennium.